From Molecular to Modular Tumor Therapy: Tumors are Reconstructible Communicatively Evolving Systems

Front Matter....Pages i-viii
Front Matter....Pages 1-1
Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients....Pages 3-7
Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options....Pages 9-28
Principles of Modular Tumor Therapy....Pages 29-47
Front Matter....Pages 49-49
Cancer and Coagulation; Focusing on Tissue Factor and Heparanase....Pages 51-74
The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity....Pages 75-96
Shaping Tumor Associated Macrophages: The Role of NF-κB....Pages 97-110
The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target....Pages 111-132
Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients?....Pages 133-157
Front Matter....Pages 159-159
Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins....Pages 161-189
Molecular Cross-Talk Between Nuclear Receptors and Nuclear Factor-κB....Pages 191-242
The Biomodulatory Capacities of Low-Dose Metronomic Chemotherapy: Complex Modulation of the Tumor Microenvironment....Pages 243-262
Front Matter....Pages 263-263
Systems Biology: A Therapeutic Target for Tumor Therapy....Pages 265-285
The Comparative Uncovering of Tumor Systems Biology by Modularly Targeting Tumor-Associated Inflammation....Pages 287-303
Searching for the ‘Metabolism’ of Evolution....Pages 305-309
Front Matter....Pages 311-311
The Impact of Inflammation Control and Active Cancer Palliation on Metabolic Pathways Determining Tumor Progression and Patient Survival....Pages 313-340
Pioglitazone and Rofecoxib Combined with Angiostatically Scheduled Capecitabine in Far-Advanced Hepatobiliary Carcinoma....Pages 341-352
C-Reactive Protein As a Secretome-Derived Biomarker for Predicting Response to Biomodulatory Therapy in Metastatic Renal Clear Cell Carcinoma....Pages 353-366
Modular Therapy Approach in Metastatic Castration-Resistent Prostate Cancer....Pages 367-377
Systems-Directed Therapy in Metastatic Castration-Resistent Prostate Cancer (CRCP)....Pages 379-382
Front Matter....Pages 383-383
Early Detection of Systems Response: Molecular and Functional Imaging of Angiogenesis....Pages 385-403
Front Matter....Pages 383-383
Secretome Proteomics, a Novel Tool for Biomarkers Discovery and for Guiding Biomodulatory Therapy Approaches....Pages 405-431
Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma....Pages 433-465
Front Matter....Pages 467-467
Uncovering Tumor Systems Biology by Biomodulatory Therapy Strategies....Pages 469-481
Breathing New Life into Old Drugs: Indication Discovery by Systems Directed Therapy....Pages 483-503
Front Matter....Pages 505-505
A Methodological Approach to Personalized Therapies in Metastatic Cancer....Pages 507-533
Front Matter....Pages 535-535
To Be an Object in a Biological System....Pages 537-544
From Molecular to Modular, from Theme-Dependent to Evolution-Adjusted Tumor Therapy....Pages 545-556
Back Matter....Pages 557-566